Job Description

Principal Scientist, Structural and Biophysical Analytics Job ID REQ-10041575 Feb 20, 2025 USA Summary The Structural BioAnalytics (SBA) group within Global Discovery Chemistry at Novartis Biomedical Research in Emeryville, CA (San Francisco Bay Area) is seeking a self-motivated, highly skilled scientist with extensive experience in structural biology analytical techniques. Candidates with a strong background in one or more of the following technologies are strongly encouraged to apply: protein mass spectrometry (MS) techniques such as hydrogen-deuterium exchange MS (HDX-MS), native MS (nMS), hydroxyl radical protein footprinting (HRPF), or Biomolecular NMR (Bio-NMR). We expect the successful candidate to be curious about new drug discovery approaches, eager to learn and to adapt quickly to the evolving needs and priorities of the SBA group. While solid hands-on experience of LC-MS, HPLC/UHPLC is preferred, we invest in our employees’ growth and offer various professional development opportunities including technical training and mentorship programs. Knowledge of other biochemical, biophysical, and cellular screening techniques for small molecule characterization and development is a plus. About the Role Internal Job Title: Principal Scientist I/II The Principal Scientist will be an integral member of structure-based drug discovery teams. They will provide structural MS and/or NMR expertise to advance early drug discovery efforts, design and conduct HDX-MS, native MS, and/or Bio-NMR experiments to solve key scientific questions, communicate effectively and efficiently in team meetings, review sessions, and collaboratively work with other scientists to develop innovative medicines. This role will impact our local discovery efforts and the global discovery portfolio through bench-level and strategic contributions. The successful candidate will be expected to implement novel structural MS and/or Bio-NMR techniques to answer drug discovery questions related to protein dynamics/folding, mutant analysis, epitope/paratope mapping, and protein/nucleic acid-small molecule interactions. Key Responsibilities: Interpret data, present results and provide strategic input to internal project teams and global stakeholders to help drive our drug discovery projects. Prepare HDX-MS samples as well as record and analyze deuterium labeling data of proteins in complex with peptides, nucleic acids, or small molecules. Prepare, execute, and analyze native MS experiments. Design, execute, and interpret Biomolecular NMR experiments. Independently support multiple drug discovery projects in parallel. Work closely with scientists in Protein Sciences to creatively design and generate protein constructs suitable for nMS, HDX-MS, or Bio-NMR experiments. Participate in maintaining our HDX-MS automation platform with associated computing and robotics. Work with in-house structural biology and drug discovery databases. Share lab and office tasks, such as ordering reagents, organizing inventories, and keeping experimental records, with other team members. Contribute intellectually to structure-based drug discovery projects and collaborate with partners from other disciplines like disease biology, biochemistry, chemistry, bioinformatics, CADD, and IT. Minimum Qualifications: A degree in Biophysics, Chemistry, Biochemistry, or related field. B.S. or M.S. with at least 10 years, or Ph.D. with at least 2 years of relevant post-graduate experience in either an academic or industrial setting. Solid background in one or more of the following techniques: analytical chemistry, mass spectrometry, Biomolecular NMR, protein biochemistry, or separation science as demonstrated by authored publications in peer-reviewed journals. Successfully demonstrated initiative, teamwork, collaboration, and a can-do attitude. Flexibility to accommodate rapidly changing priorities and deadlines, with strong interpersonal, written & oral communication, and problem-solving skills. Desired Skills: Hands-on experience with the operation and troubleshooting of mass spectrometers used for structural MS and associated equipment, in addition to experience with Trajan HDX automation platforms. Protein design, expression, and purification knowledge as well as conceptual familiarity with one or more structural biology techniques such as XRC, cEM, SPR, DSF, ITC. Familiarity with mass spectrometry peptide mapping techniques like Top N and Data-Independent Acquisition (DIA) workflows. Knowledge of R and Python for MS data analysis. Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Commitment to Diversity and Inclusion / EEO: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion, or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. #J-18808-Ljbffr Novartis Farmacéutica

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